N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide

N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide - Names and Identifiers

Name	N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide
Synonyms	C-178 N-(3-DIBENZOFURANYL)-5-NITRO-2-FURANCARBOXAMIDE N-(3-Dibenzofuranyl)-5-nitro-2-furancarboxamide 2-Furancarboxamide, N-3-dibenzofuranyl-5-nitro- N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide
CAS	329198-87-0

N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide - Physico-chemical Properties

Molecular Formula	C17H10N2O5
Molar Mass	322.27
Density	1.506±0.06 g/cm3(Predicted)
Melting Point	>225°C (dec.)
Boling Point	448.3±35.0 °C(Predicted)
Solubility	DMSO : 41.67 mg/mL (129.30 mM; Need ultrasonic)
Appearance	solid
Color	Orange
pKa	11.35±0.43(Predicted)
Storage Condition	2-8°C
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
In vitro study	C-178 targets the poorly characterized N-terminal portion of mmSTING that includes the transmembrane domains. Moreover, C-178 interferes with this process by inhibiting the palmitoylation of STING. C-178 does not appreciably affect STING responses in human cells.C-178 (0-1 μM; 1 hour) alone does not appreciably affect the gene expression profile of BMDMs. In addition, it inhibits the CMA-induced phosphorylation of TBK1.C-178 (1 μM; 1 hour) decreases cdG, dsDNA, CMA and LPS-induced Ifnb1 expression in mouse bone marrow-derived macrophages.C-178 (1 μM; 0.5-4 hours) inhibits the CMA-induced p-TBK1 and sting protein expression as a time-dependent manner in mouse embryonic fibroblasts. Western Blot Analysis Cell Line: Mouse bone marrow-derived macrophages (BMDMs) Concentration: 0 μM; 0.125 μM; 0.25 μM; 0.5 μM; 1 μM Incubation Time: 1 hour Result: Inhibited CMA-induced p-TBK1 expression as a does dependent manner. RT-PCR Cell Line: Mouse bone marrow-derived macrophages (BMDMs) Concentration: 1 μM Incubation Time: 1 hour Result: Downregulated Ifnb1 expression in BMDMs.

N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	3.103 ml	15.515 ml	31.03 ml
5 mM	0.621 ml	3.103 ml	6.206 ml
10 mM	0.31 ml	1.551 ml	3.103 ml
5 mM	0.062 ml	0.31 ml	0.621 ml

Last Update：2024-01-02 23:10:35

N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide - Introduction

N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide is an organic compound with the formula N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide. The following is a description of the properties, uses, formulation and safety information of N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide:

Nature:
N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide is a white solid with a unique chemical structure. Its physical properties such as density and melting point depend on specific structural details, because N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide is not a specific compound name, it is a reference number for a catalyst or ligand.

Use:
Because N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide can be used as a chemical reagent or catalyst, it has a wide range of applications in organic synthesis and chemical reactions. It may be used to catalyze organic reactions, synthesize organic compounds, or as a reactive intermediate.

Preparation Method:
The preparation method of N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide depends on the specific structural details, because this compound is used as a reference number rather than a specific chemical name. It is usually prepared by organic synthesis methods, including chemical reactions, ligand coordination and so on.

Safety Information:
For the security information of N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide, limited information is available for its specific structure. In general, please note the following safety measures:
-Wear appropriate personal protective equipment such as lab gloves, goggles and lab coats when operating N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide.
-Avoid direct contact with N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide, and keep the operation area well ventilated.
-Follow standard operating procedures for the storage and handling of chemicals.
-In the event of accidental exposure to or ingestion of N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide, seek immediate medical assistance and provide accurate information about the compound to your doctor.

It should be noted that since N-(dibenzo [B, d]furan-3-yl)-5-nitrofuran-2-carboxamide is not a specific compound name, the above information is only a general introduction, it is not specific to a particular compound. Prior to actual use, the compound-specific literature or references should be consulted for more detailed and accurate information.

Last Update：2024-04-10 22:29:15